We investigate various histone acetylations and their role in chromatin structure and function in regulation of vertebrate genome. We particularly focus on deciphering the role of histone H4 tail acetylations (H4K16ac) and H3 tail (H3K27ac) and globular domain acetylations (H3K122ac).
KATS and BETs
We investigate the role of lysine acetyl transferases (KAT) and bromo- and extra-terminal domain proteins (BET), BRD4, BRD3 and BRD2 in stem cells, neuronal lineage and cancers.
We study the role of chromatin proteins associated with transcription, DNA repair. Particularly our lab has long standing interest in investigating the role of a transcriptional coactivator PSIP1 in development and diseases.
We investigate how noncoding variants at cis regulatory elements contribute to disease
We focus on cancer associated variants and variants detected in neurodevelopmental disorders